Representative of Case History #2 Guillain-Barré Syndrome (GBS) •acute inflammatory demyelinating polyneuropathy •disorder of the peripheral nerves •attack of the myelin sheath of nerves by antibodies or white blood cells •rapid onset of ascending paralysis •begins with weakness and/or abnormal sensations of the legs and arms •breathing muscles may be so weakened •following gastrointestinal or respiratory viral infections •palpitations (sensation of feeling heartbeat), difficulty beginning to urinate, incomplete bladder emptying, incontinence (leaking of urine), constipation, and muscle contractions
Representative of Case History #2 •in A, patient is attempting to raise eyelids as high as possible MYASTHENIA GRAVIS •In B, same patient has had an iv injection of Tensilon, an acetylcholinsterase inhibitor. Eyelids go higher for a while A B
Representative of Case History #5 Amytropic Lateral Sclerosis Why are the spinal nerves smaller (shrunken) on the right cord??? Is there both upper and lower motor neuron disease? Is this also called Lou Gehrig Disease? Are there fasciculations?
What are the big white bundles surrounding the 4th ventricle? The melanin containing “black spots” is/are the locus coeruleus (contains nor-epi cells). We cover it in the third module. What pathways are affected by the lesion? Does it looks like level 7 without the myelin stained??