Work Breakdown Schedule Aaron 145 hrs Matt 148 hrs 1.1 Review General Air Foil Theory 6 hrs 1.1 Review General Air Foil Theory 6 hrs 1.2 Preliminary Senior Design Coordinator Meetings 2 hrs 1.2 Preliminary Senior Design Coordinator Meetings 2 hrs 1.3 Examine Existing RC Planes 12 hrs 1.3 Examine Existing RC Planes 12 hrs 1.4.1 Select Competition Class 10 hrs 1.4.1 Select Competition Class 10 hrs 10 hrs 1.4.2 Review Selected Class Requirements 10 hrs 2.1.1 Review Existing Wing Designs 8 hrs 2.2.1 Existing Technology Review 9 hrs 2.1.2 Select Basic Wing Layout 9 hrs 2.2.2 Theoretical Propeller Design 9 hrs 2.1.3 Theoretical Design of Wing 18 hrs 2.2.3 Computer Aided Propeller Analysis 9 hrs 2.1.4 Computer Aided Wing Analysis 14 hrs 2.2.4 Physical Modeling 9 hrs 2.1.5 Physical Modeling 10 hrs 2.3.1 Aerodynamic Review 6 hrs 3.1 Combine Wing, Propeller, Fuselage Models 2 hrs 2.3.2 Theoretical Fuselage Design 8 hrs 3.2 Wind Tunnel Testing 2 hrs 2.3.3 Computer Aided Fuselage Design 6 hrs 3.3 Analyze Results 1 hr 2.3.4 Physical Modeling 4 hrs 4.1.1 Project Proposal 4 hrs 3.1 Combine Wing, Propeller, Fuselage Models 2 hrs 4.1.2 Semester Report 14 hrs 3.2 Wind Tunnel Testing 2 hrs 4.2.1 Project Proposal 4 hrs 3.3 Analyze Results 1 hr 4.2.2 Semester Report Brett 19 hrs 148 hrs 4.1.1 Project Proposal 4 hrs 4.1.2 Semester Report 14 hrs 1.1 Review General Air Foil Theory 6 hrs 4.2.1 Project Proposal 6 hrs 1.2 Preliminary Senior Design Coordinator Meetings 2 hrs 4.2.2 Semester Report 19 hrs 1.3 Examine Existing RC Planes 12 hrs Tzvee 145 hrs 1.4.1 Select Competition Class 10 hrs 1.1 Review General Air Foil Theory 6 hrs 1.4.2 Review Selected Class Requirements 10 hrs 1.2 Preliminary Senior Design Coordinator Meetings 2 hrs 2.2.1 Existing Technology Review 9 hrs 1.3 Examine Existing RC Planes 12 hrs 2.2.2 Theoretical Propeller Design 9 hrs 1.4.1 Select Competition Class 10 hrs 2.2.3 Computer Aided Propeller Analysis 9 hrs 1.4.2 Review Selected Class Requirements 10 hrs 2.2.4 Physical Modeling 9 hrs 1.5 Establish Requirements Matrix 4 hrs 2.3.1 Aerodynamic Review 6 hrs 2.1.1 Review Existing Wing Designs 8 hrs 2.1.2 Select Basic Wing Layout 9 hrs 2.3.2 Theoretical Fuselage Design 8 hrs 2.1.3 Theoretical Design of Wing 18 hrs 2.3.3 Computer Aided Fuselage Design 6 hrs 2.1.4 Computer Aided Wing Analysis 14 hrs 2.3.4 Physical Modeling 4 hrs 2.1.5 Physical Modeling 10 hrs 3.1 Combine Wing, Propeller, Fuselage Models 2 hrs 3.1 Combine Wing, Propeller, Fuselage Models 2 hrs 3.2 Wind Tunnel Testing 2 hrs 3.2 Wind Tunnel Testing 2 hrs 3.3 Analyze Results 1 hr 3.3 Analyze Results 1 hr 4.1.1 Project Proposal 4 hrs 4.1.1 Project Proposal 4 hrs 4.1.2 Semester Report 14 hrs 4.1.2 Semester Report 14 hrs 4.2.1 Project Proposal 6 hrs 4.2.1 Project Proposal 0 hrs 4.2.2 Semester Report 19 hrs 4.2.2 Semester Report 19 hrs 1.4.2 Review Selected Class Requirements
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Study Requirements Estimated minimum study time required per Level  Level I – 15 hrs per week for 18 weeks  Level II – 15 hrs per week for 18 weeks  Level III – 15 hrs per week for 18 weeks Suggest one week of study per study session through late April to allow the final month for review. CFA Institute
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NSU’s NSU’s 17 17 Academic Academic Institutes Institutes  Brief Therapy Institute  Lifelong Learning Institute  Community Resolution Services  National Coral Reef Institute  Criminal Justice Institute Brief Therapy Institute   The Eye Institute Community Resolution Services  Options National Coral Reef Institute  Guy Harvey Research Institute Criminal Justice Institute     Hudson The EyeInstitute Instituteof Entrepreneurship and Executive Education Guy Harvey Research Institute  Institute of Trauma and Victimization Hudson Institute of International Institute Franchise Entrepreneurship andfor Executive  Education Education  Southeast Rumbaugh-Goodwin Institute for Institute for Cross-  Institute of Trauma and Victimization   Tyler Institute Institute The Language  International Institute for Franchise Education   Women’s Tyler Institute Resource       National Lifelong Learning Institute Institute for Educational Rumbaugh-Goodwin Institute for National Institute for Educational Cancer Research Options CancerCounseling Research Cultural Southeast Institute for Cross South Florida Ocean Cultural Counseling Measurement Center  South Florida Ocean The LanguageCenter Institute Measurement Institute Women’s Resource Institute
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UMMSM CURRICULUM (MD) (5 weeks) P B L Epi 2 Fdn Onc Nov/Dec Renal System (5 weeks) Doctoring GI & Nutritio n Sept/Oct P B L (5 weeks) Patient Safety Transitio n to Wards Core Clerkships (8, 6 or 4 weeks)  Feb Mar Apr P B L Endocri ne & Repro System Hem e -Onc (4 Weeks) (5 weeks) Doctoring IV  Core Clerkships (8, 6 or 4 weeks) OSCEs Required Clerkship/Electives Required Clerkship/Electives Graduation May Winter Break June Year 4 an ( 8 weeks) June Winter Break Year 3 Orientation June J Respiratory System Doctoring III  Orientation Year 2 (2 weeks) Aug Doctoring II Neuroscie nce & Behavior al Science May P B L  Competency Assessment Week USMLE Preparation Doctoring I  B L Spring Break (8 weeks) June P PB L Vacation (4 weeks) B L Apr/May Cellul Cardioar vascular System Functi (8 weeks) on & Epidemiolog Reguy lation (concurrent (4 CVS) weeks) w/ Competency Assessment Week (8 weeks) P PB L Spring Break Molecu lar Basis of Life Human Struct ure Host Defens es Pathog en & Patholo gy Feb/Mar (4 weeks) Jan CBL Inflam/DI Nov Competenc y Oct Winter Break Orientation Year 1 Orientation DermOphtho Doctoring Courses • Clinical Skills • Communication Skills • Health Informatics & Info • Ethics/ Professionalism • Geriatrics/Pallia tive/ Pain • Population Health Problem • Special Based Learning Populations • Patient & Infection Safety/QI Inflammation • Rheumatology Systems Based • Infectious Care Diseases Organ System Modules  Core Modules  Aug Winter Break • Embryology • Histology • Gross Anatomy • Medical Genetics • Biochemistry • Cell Biology • Cellular Biophysics • Intro to Pharmacology • Immunology • Microbiology • Intro to Pathology Core Clerkships IM 8 weeks Surgery 8 weeks OB/GYN 6 weeks Psychiatry 6 weeks Pediatrics 6 Required weeks clerkship/Electives ElectivesA 6 4 Subinternship weeksweeks GPC Subinternship B 4 4 weeks weeks Family Med 4 Geriatrics 4 weeks weeks EMed 4 weeks Radiology 4 weeks Neurology 4 weeks Anesthesia 2
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4 5 6 7 8 9 10 11 12 calendar.leapdays(y1,y2) Returns the total number of leap days in the years within range(y1,y2). calendar.month(year,month,w=2,l=1) Returns a multiline string with a calendar for month month of year year, one line per week plus two header lines. w is the width in characters of each date; each line has length 7*w+6. l is the number of lines for each week. calendar.monthcalendar(year,month) Returns a list of lists of ints. Each sublist denotes a week. Days outside month month of year year are set to 0; days within the month are set to their day-ofmonth, 1 and up. calendar.monthrange(year,month) Returns two integers. The first one is the code of the weekday for the first day of the month month in year year; the second one is the number of days in the month. Weekday codes are 0 (Monday) to 6 (Sunday); month numbers are 1 to 12. calendar.prcal(year,w=2,l=1,c=6) Like print calendar.calendar(year,w,l,c). calendar.prmonth(year,month,w=2,l=1) Like print calendar.month(year,month,w,l). calendar.setfirstweekday(weekday) Sets the first day of each week to weekday code weekday. Weekday codes are 0 (Monday) to 6 (Sunday). calendar.timegm(tupletime) The inverse of time.gmtime: accepts a time instant in time-tuple form and returns the same instant as a floating-point number of seconds since the epoch. calendar.weekday(year,month,day) Returns the weekday code for the given date. Weekday codes are 0 (Monday) to 6 (Sunday); month numbers are 1 (January) to 12 (December).
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Time Barbie Tootle Hayes Cape Cartoon Room I Cartoon Room II Suzanne M. Scharer Rosa M. Ailabouni Monday Aug 5th, 2013 10:10-11:50 A1L-A Analog Circuits I Chr: Ming Gu, Shantanu Chakrabartty Track: Analog and Mixed Signal Integrated Circuits A1L-B Low Power Digital Circuit Design Techniques A1L-C Chr: Joanne Degroat Student Contest I Track: Digital Integrated Chr: Mohammed Ismail Circuits, SoC and NoC Track: INVITED ONLY A1L-D Design and Analysis for Power Systems and Power Electronics Chr: Hoi Lee, Ayman Fayed Track: Power Systems and Power Electronics A1L-E Design and Analysis of Linear and Non-Linear Systems Chr: Samuel Palermo Track: Linear and Non-linear Circuits and Systems A1L-F Emerging Technologues Chr: Khaled Salama Track: Emerging Technologies Monday Aug 5th, 2013 13:10-14:50 A2L-A Analog Circuits II Chr: Ming Gu, Shantanu Chakrabartty Track: Analog and Mixed Signal Integrated Circuits A2L-B Low Power VLSI Design Methodology Chr: Genevieve Sapijaszko Track: Digital Integrated Circuits, SoC and NoC A2L-C Student Contest II Chr: Sleiman Bou-Sleiman Track: INVITED ONLY A2L-D Power Management and Energy Harvesting Chr: Ayman Fayed, Hoi Lee Track: Power Management and Energy Harvesting A2L-E Oscillators and Chaotic Systems Chr: Samuel Palermo, Warsame Ali Track: Linear and Non-linear Circuits and Systems A2L-F Bioengineering Systems Chr: Khaled Salama Track: Bioengineering Systems and Bio Chips A4L-A Analog Design Techniques I Chr: Dong Ha Track: Analog and Mixed Signal Integrated Circuits A4L-B Imaging and Wireless Sensors Chr: Igor Filanovsky Track: Analog and Mixed Signal Integrated Circuits A4L-C Special Session: Characterization of Nano Materials and Circuits Chr: Nayla El-Kork Track: SPECIAL SESSION A4L-D Special Session: Power Management and Energy Harvesting Chr: Paul Furth Track: SPECIAL SESSION A4L-E Communication and Signal Processing Circuits Chr: Samuel Palermo Track: Linear and Non-linear Circuits and Systems A4L-F Sensing and Measurement of Biological Signals Chr: Hoda Abdel-Aty-Zohdy Track: Bioengineering Systems and Bio Chips B2L-A Analog Design Techniques II Chr: Valencia Koomson Track: Analog and Mixed Signal Integrated Circuits B2L-B VLSI Design Reliability Chr: Shantanu Chakrabartty, Gursharan Reehal Track: Digital Integrated Circuits, SoC and NoC B2L-D B2L-C Special Session: University and Delta-Sigma Modulators Industry Training in the Art of Chr: Vishal Saxena Electronics Track: Analog and Mixed Signal Chr: Steven Bibyk Integrated Circuits Track: SPECIAL SESSION B2L-E Radio Frequency Integrated Circuits Chr: Nathan Neihart, Mona Hella Track: RFICs, Microwave, and Optical Systems B2L-F Bio-inspired Green Technologies Chr: Hoda Abdel-Aty-Zohdy Track: Bio-inspired Green Technologies B3L-A Analog Design Techniques III Chr: Valencia Koomson Track: Analog and Mixed Signal Integrated Circuits B3L-B VLSI Design, Routing, and Testing Chr: Nader Rafla Track: Programmable Logic, VLSI, CAD and Layout B3L-C Special Session: High-Precision and High-Speed Data Converters I Chr: Samuel Palermo Track: SPECIAL SESSION B3L-D B3L-E Special Session: Advancing the RF/Optical Devices and Circuits Frontiers of Solar Energy Chr: Mona Hella, Nathan Neihart Chr: Michael Soderstrand Track: RFICs, Microwave, and Track: SPECIAL SESSION Optical Systems B5L-A Nyquist-Rate Data Converters Chr: Vishal Saxena Track: Analog and Mixed Signal Integrated Circuits B5L-B Digital Circuits Chr: Nader Rafla Track: Programmable Logic, VLSI, CAD and Layout B5L-C Special Session: High-Precision and High-Speed Data Converters II Chr: Samuel Palermo Track: SPECIAL SESSION B5L-D Special Session: RF-FPGA Circuits and Systems for Enhancing Access to Radio Spectrum (CAS-EARS) Chr: Arjuna Madanayake, Vijay Devabhaktuni Track: SPECIAL SESSION B5L-E B5L-F Analog and RF Circuit Memristors, DG-MOSFETS and Techniques Graphine FETs Chr: Igor Filanovsky Chr: Reyad El-Khazali Track: Analog and Mixed Signal Track: Nanoelectronics and Integrated Circuits Nanotechnology C2L-A Phase Locked Loops Chr: Chung-Chih Hung Track: Analog and Mixed Signal Integrated Circuits C2L-B Computer Arithmetic and Cryptography Chr: George Purdy Track: Programmable Logic, VLSI, CAD and Layout C2L-C Special Session: Reversible Computing Chr: Himanshu Thapliyal Track: SPECIAL SESSION C2L-D Special Session: Self-healing and Self-Adaptive Circuits and Systems Chr: Abhilash Goyal, Abhijit Chatterjee Track: SPECIAL SESSION C2L-E Digital Signal Processing-Media and Control Chr: Wasfy Mikhael, Steven Bibyk Track: Digital Signal Processing C2L-F Advances in Communications and Wireless Systems Chr: Sami Muhaidat Track: Communication and Wireless Systems C3L-A SAR Analog-to-Digital Converters Chr: Vishal Saxena Track: Analog and Mixed Signal Integrated Circuits C3L-B Real Time Systems Chr: Brian Dupaix, Abhilash Goyal Track: System Architectures C3L-C Image Processing and Interpretation Chr: Annajirao Garimella Track: Image Processing and Multimedia Systems C3L-D Special Session: Verification and Trusted Mixed Signal Electronics Development Chr: Greg Creech, Steven Bibyk Track: SPECIAL SESSION C3L-E Digital Signal Processing I Chr: Ying Liu Track: Digital Signal Processing C3L-F Wireless Systems I Chr: Sami Muhaidat Track: Communication and Wireless Systems C5L-A Wireless Systems II Chr: Sami Muhaidat Track: Communication and Wireless Systems C5L-B System Architectures Chr: Swarup Bhunia, Abhilash Goyal Track: System Architectures C5L-C Image Embedding Compression and Analysis Chr: Annajirao Garimella Track: Image Processing and Multimedia Systems C5L-D Low Power Datapath Design Chr: Wasfy Mikhael Track: Digital Integrated Circuits, SoC and NoC C5L-E Digital Signal Processing II Chr: Moataz AbdelWahab Track: Digital Signal Processing C5L-F Advances in Control Systems, Mechatronics, and Robotics Chr: Charna Parkey, Genevieve Sapijaszko Track: Control Systems, Mechatronics, and Robotics Monday Aug 5th, 2013 16:00-17:40 Tuesday Aug 6th, 2013 10:10-11:50 Tuesday Aug 6th, 2013 13:10-14:50 Tuesday Aug 6th, 2013 16:00-17:40 Wednesday Aug 7th, 2013 10:10-11:50 Wednesday Aug 7th, 2013 13:10-14:50 Wednesday Aug 7th, 2013 16:00-17:40 B3L-F Carbon Nanotube-based Sensors and Beyond Chr: Nayla El-Kork Track: Nanoelectronics and Nanotechnology 5
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Timeline Timeline from July 18, 2004 (proposal due date).  Identify Objectives – August 1 (2 weeks)  Outline Content  General outline – August 8 (3 weeks)  Content written – August 22 (5 weeks)  Content revised and final – September 5 (7 weeks)  Outline Navigation  General outline – August 22 (5 weeks)  Navigation mapped – August 29 (6 weeks)  Navigation revised and final – September 8 (7 ½ weeks)  Storyboard Site  First storyboard session – September 6 (7 weeks+)  Rough storyboards due – September 12 (8 weeks)  Storyboard revision session – September 13 (8 weeks+)  Final storyboards due – September 19 (9 weeks)     Develop Site  First development session – September 20 (9 weeks+)  Last development session – October 10 (12 weeks) Test Site  Internal tests performed – October 11 (12 weeks+)  External tests performed – October 19 (13 weeks+) Modify Site (if needed)  Ongoing modifications as tests indicate.  Final modifications done – October 31 (15 weeks) Publish Site – November 1 (15 weeks) Total time from proposal due date to site publication: 15 weeks
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Design TA Time Commitment TA Student Load Hourly Breakdown 10 hrs/week 1 section 38 students max Hrs in class/week = 3 Office Hours = 1 Resource Room Hours = 1 Weekly Meeting = 1 Scheduled time total = 6 hrs Open time = 4 hrs 15 hrs/week 2 sections 76 students max Hrs in class/week = 6 Office Hours = 1 Resource Room Hours = 1 Weekly Meeting = 1 Scheduled time total = 9 hrs Open time = 6 hrs 20 hrs/week 3 sections 114 students max Hrs in class/week = 9 Office Hours = 1 Resource Room Hours = 1 Weekly Meeting = 1 Scheduled time total = 12 hrs Open time = 8 hrs A D D I E
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It’s really not this bad! Office Officeofofthe theDirector Director National NationalInstitute Institute on onAging Aging National NationalInstitute Institute on onAlcohol AlcoholAbuse Abuse and andAlcoholism Alcoholism National NationalInstitute Institute ofofAllergy Allergyand and Infectious InfectiousDiseases Diseases National NationalInstitute Institute ofofArthritis Arthritisand and Musculoskeletal Musculoskeletal and andSkin SkinDiseases Diseases National NationalCancer Cancer Institute Institute Eunice EuniceKennedy Kennedy Shriver ShriverNational NationalInstitute Institute ofofChild ChildHealth Healthand and Human HumanDevelopment Development National NationalInstitute Instituteon on Deafness Deafnessand andOther Other Communication Communication Disorders Disorders National NationalInstitute Institute ofofDental Dentaland and Craniofacial Craniofacial Research Research National NationalInstitute Institute ofofDiabetes Diabetesand and Digestive Digestiveand and Kidney Diseases Kidney Diseases National NationalInstitute Institute on onDrug DrugAbuse Abuse National NationalInstitute Institute ofofEnvironmental Environmental Health Sciences Health Sciences National NationalEye Eye Institute Institute National NationalInstitute Institute ofofGeneral General Medical Sciences Medical Sciences National NationalHeart, Heart, Lung, Lung,and andBlood Blood Institute Institute National NationalHuman Human Genome GenomeResearch Research Institute Institute National NationalInstitute Institute ofofMental MentalHealth Health National NationalInstitute Institute ofofNeurological Neurological Disorders Disordersand and Stroke Stroke National NationalInstitute Institute ofofNursing NursingResearch Research National NationalCenter Center for forComplementary Complementary and Alternative and Alternative Medicine Medicine John JohnE. E.Fogarty Fogarty International International Center Center National NationalCenter Center for forResearch Research Resources Resources National NationalLibrary Library ofofMedicine Medicine National NationalInstitute Instituteofof Biomedical BiomedicalImaging Imaging and andBioengineering Bioengineering Clinical ClinicalCenter Center Understanding NIH Center Centerfor for Information Information Technology Technology Slide 10 National NationalInstitute Instituteon on Minority MinorityHealth Healthand and Health Disparities Health Disparities Center Centerfor for Scientific ScientificReview Review 8 November 2017
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National Institutes of Health Office Officeof ofthe theDirector Director National NationalInstitute Institute on onAging Aging National NationalInstitute Institute on onAlcohol AlcoholAbuse Abuse and andAlcoholism Alcoholism National NationalInstitute Institute of ofAllergy Allergyand and Infectious InfectiousDiseases Diseases National NationalInstitute Institute of ofArthritis Arthritisand and Musculoskeletal Musculoskeletal and andSkin SkinDiseases Diseases National NationalCancer Cancer Institute Institute National NationalInstitute Institute of ofChild ChildHealth Health and andHuman Human Development Development National NationalInstitute Instituteon on Deafness Deafnessand andOther Other Communication Communication Disorders Disorders National NationalInstitute Institute of ofDental Dentaland and Craniofacial Craniofacial Research Research National NationalInstitute Institute of ofDiabetes Diabetesand and Digestive Digestiveand and Kidney KidneyDiseases Diseases National NationalInstitute Institute on onDrug DrugAbuse Abuse National NationalInstitute Institute of ofEnvironmental Environmental Health HealthSciences Sciences National NationalEye Eye Institute Institute National NationalInstitute Institute of ofGeneral General Medical MedicalSciences Sciences National NationalHeart, Heart, Lung, Lung,and andBlood Blood Institute Institute National NationalHuman Human Genome GenomeResearch Research Institute Institute National NationalInstitute Institute of ofMental MentalHealth Health National NationalInstitute Institute of ofNeurological Neurological Disorders Disordersand and Stroke Stroke National NationalInstitute Institute of ofNursing NursingResearch Research National NationalInstitute Instituteof of Biomedical BiomedicalImaging Imaging and andBioengineering Bioengineering National NationalCenter Center for forComplementary Complementary and andAlternative Alternative Medicine Medicine Fogarty Fogarty International International Center Center National NationalCenter Center for forResearch Research Resources Resources National NationalLibrary Library of ofMedicine Medicine National NationalCenter Centeron on Minority Health Minority Healthand and Health HealthDisparities Disparities Clinical ClinicalCenter Center Center Centerfor for Information Information Technology Technology Center for Scientific Review
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Carbapenem Activity Against Acinetobacter calcoaceticus-baumanii complex (ACBC) in an In Vitro Pharmacokinetic Bacteremia Model (PKM) Eric G Sahloff, Pharm.D., Diane M. Cappelletty, Pharm.D., & Steven J. Martin, Pharm.D., BCPS, FCCM College of Pharmacy, University of Toledo, 2801 W. Bancroft St., Toledo, Ohio 43606 ABSTRACT Our ICU has experienced an outbreak of multi-drug resistant AC, with isolates susceptible only to carbapenems and aminoglycosides. Imipenem (IC) has become an empiric choice for therapy in nosocomial pneumonia and bacteremia in our ICU. Meropenem (M) has become a financially attractive option to IC. The purpose of this study was to compare the bactericidal effects of IC to M against AC clinical isolates using an in vitro PKM. Four AC clinical isolates were tested in a PKM simulating M 1 g q8 hrs and IC 500 mg q6 hrs over 48 hrs. All isolates were susceptible to M and IC with MICs of 1 g/ml and 0.25-0.5 g/ml, respectively. Samples were taken from the model at several time points over the 48 hrs to evaluate killing and PK. MIC and MBCs were determined at time 0, 24 hrs, and 48 hrs. The rates of bacterial killing and area under the bactericidal curves (AUBC) were compared. Isolates were screened for resistant subpopulations (RS) using antibiotic-containing medium at baseline, 24 and 48 hr. For M and IC, greater than 99.9% kill was seen by 3-4 hrs in 3/4 isolates,. However, regrowth occurred by 24 hours for all isolates against M. For IC, regrowth occurred in 2/4 isolates by 24 hours and between 30-48 hrs for the remaining 2 isolates. AUBC was lower (greater extent of kill) for IC in 3/4 isolates at 12, 24, and 48 hours. Low-level RS were identified at baseline, while high-level resistance was noted for regrowth at 48 hr. M and IC had similar rates of killing with both agents being bactericidal in 3/4 isolates. IC had superior duration of bacterial killing compared to M against AC. Despite initial bactericidal activity, significant regrowth occurred for all isolates against both drugs by 48 hours. This suggests carbapenem monotherapy may select for resistant populations or induce resistance and coul lead to potential drug failure. The presence of resistant subpopulations may support the use of combination therapy in AC infections. Each drug was tested alone against each isolate. Drug was administered into the model at desired peak concentrations through an access port. Fresh sterile medium pumped into and drug-containing medium flows out of the model at a rate simulating the half-life achieved by human pharmacokinetics. All were run in duplicate at 37o C. Pharmacokinetic/Pharmacodynamic Resistance Determinations Serial samples (1.0 ml) were drawn to measure colony counts and drug concentrations To prevent antibiotic carryover, samples were centrifuged, the supernatant removed, and the bacteria resuspended in 1 ml normal saline. Samples were plated by spiral plating techniques. Antibiotic-containing agar plates at 2x and 4x MIC were evaluated at 24 and 48 hrs to detect and quantify the emergence of resistance. Endopoints were rate and extent of killing, and the development and frequency of resistance (regrowth). MIC/MBCs were performed on any regrowth for both agents to determine if resistance was drugor class-specific. Drug concentrations will be determined by bioassay. Isolate 9 Isolate 9 8 Imipenem Run 1A Imipenem Run 2A Imipenem Run 1B Imipenem Run 2B 7 6 6 5 5 4 4 Isolate 4 7 9 10 Drug Meropenem Imipenem Meropenem Imipenem Meropenem Imipenem Meropenem Imipenem Meropenem Run 1B Meropenem Run 2B 3 3 2 2 1 1 0 2 4 6 8 10 1224 30 36 42 0 48 Time (hrs) Meropenem 8 2 4 6 8 10 1224 30 36 42 48 Time (hrs) RESULTS Resistant Subpopulations (% of Total Population 24 hr 48 hr 2x MIC 4x MIC 2x MIC 4x MIC < 0.01 NG NR <0.01 NG NG <0.01 NG <0.01 <0.01 NR <0.01 <0.01 NG <0.01 NG 0.14 <0.01 NR <0.01 NG NG <0.01 NG <0.01 NG NR <0.01 <0.01 NG NR <0.01 Meropenem Run 2A 8 7 Isolate 10 Table 1. Frequency of Resistant Subpopulations Meropenem Run 1A Imipenem 7 6 5 MIC/MBC were unchanged from baseline when evaluated from samples directly from the model or from growth on drug-free agar at 24 and 48 hr wfor Isolates 9 and 10 for both M and IC No growth was noted on antibioticcontaining medium at 2x or 4x MICs for Isolates 9 or 10 at 24 or 48 hrs. 4 3 2 1 0 2 4 6 8 10 1224 Time (hrs) 30 36 42 48
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Production Scheduling  Define the constraint Reg. Hrs. Used Month 1 < Reg. Hrs. Avail. Month 1: (5) .5SR1 + .6DR1 < 1000  Define the constraint OT Hrs. Used Month 1 < OT Hrs. Avail. Month 1: (6) .5SO1 + .6DO1 < 500  Define the constraint Reg. Hrs. Used Month 2 < Reg. Hrs. Avail. Month 2: (7) .5SR2 + .6DR2 < 1000  Define the constraint OT Hrs. Used Month 2 < OT Hrs. Avail. Month 2: (8) .5SO2 + .6DO2 < 500 BA 452 Lesson A.9 Operations Management Applications 12
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Design What are the minimum staffing resources needed to deliver the proposed changes? How are they scalable? Sections Faculty TAs (minimum required) # Students 1 1 5 (1 section each) 10 hrs/week 190 2 1 5 (2 sections each) 15 hrs/week 380 3 2 5 (3 sections each) 20 hrs/week 570 4 2 7 6 (3 sections each) 20 hrs/week 1 (2 sections) 15 hrs/week 760 5 3 9 8 (3 sections each) 20 hrs/week 1 (1 section each) 10 hrs/week) -or7 (3 sections each) 20 hrs/week 2 (2 sections each) 15 hrs/week 950 A D D I E
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Building a Sample Project Enter Tasks • For this sample project enter these tasks: TASK Foundation Framing Roof Electrical Sheetrock Interior Paint Exterior Paint Landscaping Optimistic Duration Expected Duration Pessimistic Duration 1 week 2 weeks 1 week 1 week 1 week 1 week 1 week 1 week 2 weeks 4 weeks 2 weeks 2 weeks 3 weeks 2 weeks 2 weeks 2 weeks Urban and Regional Studies Institute 3 weeks 7 weeks 3 weeks 3 weeks 5 weeks 4 weeks 3 weeks 4 weeks 27
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National Institutes of Health Office of Extramural Research Office of the Director National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke Fogarty International Center National Center for Research Resources National Center on Minority Health and Health Disparities National Center for Complementary and Alternative Medicine NIH Clinical Center Center for Information Technology National Library of Medicine Center for Scientific Review National Institute of Nursing Research National Institute of Biomedical Imaging and Bioengineering No funding authority3
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Organizational Structure of NIH Office of the Director http://www.nih.gov/ic d National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Center on Minority Health and Health Disparities National Center for Complementary and Alternative Medicine Fogarty International Center National Center for Research Resources National Library of Medicine National Institute of Biomedical Imaging and Bioengineering No funding authority 18 18
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